7QPM
Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 340 | 39626.5 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (human) | |
2 | A, B | 5,7-dimethyl-2-[(1-methyl-4-phenyl-imidazol-2-yl)sulfanylmethyl]imidazo[1,2-a]pyrimidine | non-polymer | 349.5 | 2 | Chemie (EEI) | |||
3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A, B: 432 - 764 (UniProt: Q9Y233)
PDB | External Database | Details |
---|---|---|
Arg 765 | - | expression tag |
His 766 | - | expression tag |
His 767 | - | expression tag |
His 768 | - | expression tag |
His 769 | - | expression tag |
His 770 | - | expression tag |
His 771 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 79253.1 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 878.3 | |
All* | Total formula weight | 80131.4 |