7QO5
26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (a, A) | Proteasome subunit alpha type-1 | polymer | 252 | 28033.8 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit C7-alpha,Multicatalytic endopeptidase complex C7,Proteasome component C7-alpha,Proteasome component Y8,Proteinase YSCE subunit 7,SCL1 suppressor protein |
| 2 | B, P (b, B) | Proteasome subunit alpha type-2 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit Y7,Multicatalytic endopeptidase complex subunit Y7,Proteasome component Y7,Proteinase YSCE subunit 7 |
| 3 | C, Q (c, C) | Proteasome subunit alpha type-3 | polymer | 258 | 28748.2 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit Y13,Multicatalytic endopeptidase complex subunit Y13,Proteasome component Y13,Proteinase YSCE subunit 13 |
| 4 | D, R (d, D) | Proteasome subunit alpha type-4 | polymer | 254 | 28478.1 | 2 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE6,Multicatalytic endopeptidase complex subunit PRE6,Proteasome component PRE6,Proteinase YSCE subunit PRE6 |
| 5 | E, S (e, E) | Proteasome subunit alpha type-5 | polymer | 260 | 28649.1 | 2 | UniProt (P32379) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PUP2,Multicatalytic endopeptidase complex subunit PUP2,Proteasome component PUP2,Proteinase YSCE subunit PUP2 |
| 6 | F, T (f, F) | Proteasome subunit alpha type-6 | polymer | 234 | 25634.0 | 2 | UniProt (P40302) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE5,Multicatalytic endopeptidase complex subunit PRE5,Proteasome component PRE5,Proteinase YSCE subunit PRE5 |
| 7 | G, U (g, G) | Probable proteasome subunit alpha type-7 | polymer | 288 | 31575.1 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit C1,Multicatalytic endopeptidase complex subunit C1,Proteasome component C1,Proteinase YSCE subunit 1 |
| 8 | H, V (h, 1) | Proteasome subunit beta type-1 | polymer | 215 | 23573.6 | 2 | UniProt (P38624) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE3,Multicatalytic endopeptidase complex subunit PRE3,Proteasome component PRE3,Proteinase YSCE subunit PRE3 |
| 9 | I, W (i, 2) | Proteasome subunit beta type-2 | polymer | 261 | 28299.9 | 2 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PUP1,Multicatalytic endopeptidase complex subunit PUP1,Proteasome component PUP1,Proteinase YSCE subunit PUP1 |
| 10 | J, X (j, 3) | Proteasome subunit beta type-3 | polymer | 205 | 22627.8 | 2 | UniProt (P25451) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PUP3,Multicatalytic endopeptidase complex subunit PUP3,Proteasome component PUP3 |
| 11 | K, Y (k, 4) | Proteasome subunit beta type-4 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit C11,Multicatalytic endopeptidase complex subunit C11,Proteasome component C11,Proteinase YSCE subunit 11 |
| 12 | L, Z (l, 5) | Proteasome subunit beta type-5 | polymer | 287 | 31670.5 | 2 | UniProt (P30656) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE2,Multicatalytic endopeptidase complex subunit PRE2,Proteasome component PRE2,Proteinase YSCE subunit PRE2 |
| 13 | AA, M (m, 6) | Proteasome subunit beta type-6 | polymer | 241 | 26905.1 | 2 | UniProt (P23724) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Multicatalytic endopeptidase complex subunit C5,Proteasome component C5 |
| 14 | BA, N (n, 7) | Proteasome subunit beta type-7 | polymer | 266 | 29471.3 | 2 | UniProt (P30657) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE4,Multicatalytic endopeptidase complex subunit PRE4,Proteasome component PRE4,Proteinase YSCE subunit PRE4 |
| 15 | CA (W) | 26S proteasome regulatory subunit RPN10 | polymer | 268 | 29776.1 | 1 | UniProt (P38886) Pfam (PF13519) | Saccharomyces cerevisiae (baker's yeast) | |
| 16 | DA (V) | Ubiquitin carboxyl-terminal hydrolase RPN11 | polymer | 306 | 34442.3 | 1 | UniProt (P43588) Pfam (PF01398) | Saccharomyces cerevisiae (baker's yeast) | 26S proteasome regulatory subunit RPN11,Protein MPR1 |
| 17 | EA (T) | 26S proteasome regulatory subunit RPN12 | polymer | 274 | 31952.1 | 1 | UniProt (P32496) Pfam (PF10075) | Saccharomyces cerevisiae (baker's yeast) | Nuclear integrity protein 1 |
| 18 | FA (X) | 26S proteasome regulatory subunit RPN13 | polymer | 156 | 17919.0 | 1 | UniProt (O13563) Pfam (PF04683) | Saccharomyces cerevisiae (baker's yeast) | Proteasome non-ATPase subunit 13 |
| 19 | GA (Y) | 26S proteasome complex subunit SEM1 | polymer | 89 | 10397.1 | 1 | UniProt (O94742) Pfam (PF05160) | Saccharomyces cerevisiae (baker's yeast) | |
| 20 | HA (Z) | 26S proteasome regulatory subunit RPN1 | polymer | 993 | 109601.9 | 1 | UniProt (P38764) Pfam (PF17781) Pfam (PF01851) Pfam (PF18051) | Saccharomyces cerevisiae (baker's yeast) | HMG-CoA reductase degradation protein 2,Proteasome non-ATPase subunit 1 |
| 21 | IA (N) | 26S proteasome regulatory subunit RPN2 | polymer | 945 | 104351.9 | 1 | UniProt (P32565) Pfam (PF21505) Pfam (PF01851) Pfam (PF13646) Pfam (PF18004) | Saccharomyces cerevisiae (baker's yeast) | |
| 22 | JA (S) | 26S proteasome regulatory subunit RPN3 | polymer | 523 | 60464.6 | 1 | UniProt (P40016) Pfam (PF01399) Pfam (PF08375) | Saccharomyces cerevisiae (baker's yeast) | |
| 23 | KA (P) | 26S proteasome regulatory subunit RPN5 | polymer | 445 | 51840.4 | 1 | UniProt (Q12250) Pfam (PF22241) Pfam (PF01399) Pfam (PF18098) | Saccharomyces cerevisiae (baker's yeast) | Proteasome non-ATPase subunit 5 |
| 24 | LA (Q) | 26S proteasome regulatory subunit RPN6 | polymer | 434 | 49839.8 | 1 | UniProt (Q12377) Pfam (PF18055) Pfam (PF01399) Pfam (PF18503) | Saccharomyces cerevisiae (baker's yeast) | Proteasome non-ATPase subunit 4 |
| 25 | MA (R) | 26S proteasome regulatory subunit RPN7 | polymer | 429 | 49016.4 | 1 | UniProt (Q06103) Pfam (PF10602) Pfam (PF01399) Pfam (PF21154) | Saccharomyces cerevisiae (baker's yeast) | |
| 26 | NA (U) | 26S proteasome regulatory subunit RPN8 | polymer | 338 | 38365.5 | 1 | UniProt (Q08723) Pfam (PF01398) Pfam (PF13012) | Saccharomyces cerevisiae (baker's yeast) | |
| 27 | OA (O) | 26S proteasome regulatory subunit RPN9 | polymer | 393 | 45839.3 | 1 | UniProt (Q04062) Pfam (PF22037) Pfam (PF01399) Pfam (PF18261) | Saccharomyces cerevisiae (baker's yeast) | |
| 28 | PA (H) | 26S proteasome regulatory subunit 7 homolog | polymer | 467 | 52153.1 | 1 | UniProt (P33299) Pfam (PF21236) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae (baker's yeast) | Protein CIM5,Tat-binding homolog 3 |
| 29 | QA (I) | 26S proteasome regulatory subunit 4 homolog | polymer | 437 | 48898.2 | 1 | UniProt (P40327) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae (baker's yeast) | Tat-binding homolog 5 |
| 30 | RA (K) | 26S proteasome regulatory subunit 6B homolog | polymer | 428 | 47953.7 | 1 | UniProt (P33298) Pfam (PF16450) Pfam (PF00004) | Saccharomyces cerevisiae (baker's yeast) | Protein YNT1,Tat-binding homolog 2 |
| 31 | SA (L) | 26S proteasome subunit RPT4 | polymer | 437 | 49480.1 | 1 | UniProt (P53549) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae (baker's yeast) | 26S protease subunit SUG2,Proteasomal cap subunit |
| 32 | TA (M) | 26S proteasome regulatory subunit 6A | polymer | 434 | 48315.7 | 1 | UniProt (P33297) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae (baker's yeast) | Tat-binding protein homolog 1,TBP-1 |
| 33 | UA (J) | 26S proteasome regulatory subunit 8 homolog | polymer | 405 | 45342.7 | 1 | UniProt (Q01939) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Saccharomyces cerevisiae (baker's yeast) | Protein CIM3,Protein SUG1,Tat-binding protein TBY1 |
| 34 | VA (8) | Ubiquitin carboxyl-terminal hydrolase 6 | polymer | 499 | 57188.6 | 1 | UniProt (P43593) Pfam (PF00443) | Saccharomyces cerevisiae (baker's yeast) | Deubiquitinating enzyme 6,Ubiquitin thioesterase 6,Ubiquitin-specific-processing protease 6 |
| 35 | WA (9) | Polyubiquitin-B | polymer | 76 | 8560.8 | 1 | UniProt (P0CG47) Pfam (PF00240) | Homo sapiens (human) | |
| 36 | BB, DB, FB, XA, ZA (K, L, M, H, I) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 5 | Chemie (ATP) | |||
| 37 | AB, CB, EB, GB, IB... (I, K, L, M, J...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 38 | HB (J) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
H: 1 - 467 (UniProt: P33299)
| PDB | External Database | Details |
|---|---|---|
| Arg 164 | Ser 164 | variant |
| Lys 166 | Thr 166 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 49 |
| Total formula weight | 1758507.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3108.9 | |
| All* | Total formula weight | 1761616.5 |
