7QN8
Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and nanobody Nb25
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Gamma-aminobutyric acid receptor subunit beta-3 | polymer | 473 | 54180.3 | 4 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit beta-3 |
2 | E | Gamma-aminobutyric acid receptor subunit delta | polymer | 472 | 52437.9 | 1 | UniProt (O14764) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit delta |
3 | K, L, M | Nanobody Nb25 | polymer | 121 | 13341.7 | 3 | Homo sapiens | ||
4 | a, b, c, d | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
5 | F, G, H, I | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
6 | B, D | HISTAMINE | non-polymer | 111.1 | 3 | Chemie (HSM) | |||
7 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
E: 1 - 452 (UniProt: O14764)
PDB | External Database | Details |
---|---|---|
Gly 453 | - | expression tag |
Gly 454 | - | expression tag |
Ser 455 | - | expression tag |
Gly 456 | - | expression tag |
Gly 457 | - | expression tag |
Ser 458 | - | expression tag |
Gly 459 | - | expression tag |
Gly 460 | - | expression tag |
Ser 461 | - | expression tag |
Gly 462 | - | expression tag |
Lys 463 | - | expression tag |
Thr 464 | - | expression tag |
Glu 465 | - | expression tag |
Thr 466 | - | expression tag |
Ser 467 | - | expression tag |
Gln 468 | - | expression tag |
Val 469 | - | expression tag |
Ala 470 | - | expression tag |
Pro 471 | - | expression tag |
Ala 472 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 309184.5 | |
Branched | Number of molecules | 8 |
Total formula weight | 5340.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 554.6 | |
All* | Total formula weight | 315080.1 |