7QKR

Cryo-EM structure of ABC transporter STE6-2p from Pichia pastoris with Verapamil at 3.2 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Plasma membrane ATP-binding cassette transporter required for the export of a-factor	polymer	1310	144974.3	1	UniProt (F2QQK6) Pfam (PF00664) Pfam (PF00005)	Komagataella phaffii CBS 7435
2	B (A)	Dexverapamil	non-polymer		454.6	1	Chemie (I6H)
3	C (A)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
4	D (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5	E (A)	(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en	non-polymer		544.8	1	Chemie (9Z9)

Sequence modifications

A: 2 - 1288 (UniProt: F2QQK6)

PDB	External Database	Details
Met -11	-	initiating methionine
Val -10	-	expression tag
Lys -9	-	expression tag
Asn -8	-	expression tag
Tyr -7	-	expression tag
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag
His 1289	-	expression tag
His 1290	-	expression tag
His 1291	-	expression tag
His 1292	-	expression tag
His 1293	-	expression tag
His 1294	-	expression tag
His 1295	-	expression tag
His 1296	-	expression tag
His 1297	-	expression tag
His 1298	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	144974.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1529.9
All*	Total formula weight	146504.2

*Water molecules are not included.