7QKD
Crystal structure of human Cathepsin L in complex with covalently bound MG132
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cathepsin L | polymer | 220 | 24161.7 | 4 | UniProt (P07711) Pfam (PF00112) | Homo sapiens (human) | |
| 2 | E, H, J, L (A, B, C, D) | N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide | non-polymer | 477.6 | 4 | BIRD (PRD_001210) Chemie (ALD) | |||
| 3 | F, G, I, K, M... (A, B, C, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 7 | Chemie (PEG) | |||
| 4 | P (D) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 932 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96646.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2712.4 | |
| All* | Total formula weight | 99359.1 |
