7QKB
Crystal structure of human Cathepsin L in complex with covalently bound GC376
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cathepsin L | polymer | 220 | 24161.7 | 4 | UniProt (P07711) Pfam (PF00112) | Homo sapiens (human) | |
| 2 | E, I, K, L, M... (A, B, C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 7 | Chemie (PEG) | |||
| 3 | F, N, S, V (A, B, C, D) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 4 | G, O (A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 5 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | J, P, U, X (A, B, C, D) | N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide | non-polymer | 405.5 | 4 | Chemie (UED) | |||
| 7 | T (C) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 8 | W (D) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 9 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 272 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96646.7 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 3269.1 | |
| All* | Total formula weight | 99915.8 |
