7QK4
EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polycomb protein EED | polymer | 366 | 42227.1 | 1 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 2 | B (B) | Histone-lysine N-methyltransferase EZH2 | polymer | 29 | 3622.2 | 1 | UniProt (Q15910) Pfam (PF11616) | Homo sapiens | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 3 | C, D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | F (A) | N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | non-polymer | 376.4 | 1 | Chemie (EJR) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A: 77 - 441 (UniProt: O75530)
| PDB | External Database | Details |
|---|---|---|
| Gly 76 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45849.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 482.7 | |
| All* | Total formula weight | 46332.0 |
