7QHB
Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Isoform Flip of Glutamate receptor 1 | polymer | 915 | 102661.9 | 2 | UniProt (P19490) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1 |
| 2 | B, D (B, D) | Isoform Flip of Glutamate receptor 2 | polymer | 860 | 96247.1 | 2 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 3 | E, F (I, J) | Voltage-dependent calcium channel gamma-8 subunit | polymer | 423 | 43576.0 | 2 | UniProt (Q8VHW5) Pfam (PF00822) | Rattus norvegicus (Norway rat) | Neuronal voltage-gated calcium channel gamma-8 subunit,Transmembrane AMPAR regulatory protein gamma-8,TARP gamma-8 |
| 4 | AA, BA, CA, DA, EA... (I, J, A, B, C...) | PALMITOLEIC ACID | non-polymer | 254.4 | 14 | Chemie (PAM) | |||
| 5 | H, M, S, W (A, B, C, D) | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
| 6 | I, N, T, X (A, B, C, D) | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) | |||
| 7 | J, U (A, C) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 2 | Chemie (OLC) | |||
| 8 | L, O, P, Y (A, B, D) | (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate | non-polymer | 328.5 | 4 | Chemie (79N) |
Sequence modifications
A, C: -25 - 889 (UniProt: P19490)
B, D: -20 - 839 (UniProt: P19491)
I, J: 2 - 417 (UniProt: Q8VHW5)
| PDB | External Database | Details |
|---|---|---|
| Asp -6 | - | insertion |
| Tyr -5 | - | insertion |
| Lys -4 | - | insertion |
| Asp -3 | - | insertion |
| Asp -2 | - | insertion |
| Asp -1 | - | insertion |
| Asp 0 | - | insertion |
| Lys 1 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Arg 586 | Gln 607 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Leu 418 | - | expression tag |
| Glu 419 | - | expression tag |
| Val 420 | - | expression tag |
| Leu 421 | - | expression tag |
| Phe 422 | - | expression tag |
| Gln 423 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 484970.0 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 7736.8 | |
| All* | Total formula weight | 492706.7 |
