7QGT

Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with AOAA.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cystathionine beta-synthase	polymer	563	62132.9	2	UniProt (P35520) Pfam (PF00291) Pfam (PF00571)	Homo sapiens (human)	Beta-thionase,Serine sulfhydrase
2	C, E (A, B)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	D (A)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	1	Chemie (PLP)
4	F (B)	4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE	non-polymer		322.2	1	Chemie (IK2)
5	G, H (A, B)	water	water		18.0	167	Chemie (HOH)

Sequence modifications

A, B: 1 - 541 (UniProt: P35520)

PDB	External Database	Details
Met -21	-	initiating methionine
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag
-	Ile 516	deletion
-	Gln 517	deletion
-	Tyr 518	deletion
-	His 519	deletion
-	Ser 520	deletion
-	Thr 521	deletion
-	Gly 522	deletion
-	Lys 523	deletion
-	Ser 524	deletion
-	Ser 525	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	124265.9
Non-Polymers*	Number of molecules	4
	Total formula weight	1802.3
All*	Total formula weight	126068.2

*Water molecules are not included.