7QG7

SARS-CoV-2 macrodomain Nsp3b bound to the remdesivir nucleoside GS-441524

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Papain-like protease nsp3	polymer	173	18676.4	2	UniProt (P0DTD1) Pfam (PF01661)	Severe acute respiratory syndrome coronavirus 2	Non-structural protein 3,nsp3,PL2-PRO,Papain-like proteinase,PL-PRO
2	C, F (A, B)	(2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolane-2-carbonitrile	non-polymer		291.3	2	Chemie (U08)
3	D, E, G, H, I (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
4	J, K (A, B)	water	water		18.0	158	Chemie (HOH)

Sequence modifications

A, B: 3 - 172 (UniProt: P0DTD1)

PDB	External Database	Details
Gly 0	-	expression tag
His 1	-	expression tag
Met 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	37352.7
Non-Polymers*	Number of molecules	7
	Total formula weight	892.9
All*	Total formula weight	38245.6

*Water molecules are not included.