7QG2
IRAK4 in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Interleukin-1 receptor-associated kinase 4 | polymer | 308 | 34635.0 | 4 | UniProt (Q9NWZ3) Pfam (PF07714) | Homo sapiens (human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | E, F, G, H (A, B, C, D) | 6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | non-polymer | 408.5 | 4 | Chemie (B6I) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 154 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 153 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138540.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1634.0 | |
| All* | Total formula weight | 140174.0 |
