7QE7
High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | L | Anaphase-promoting complex subunit 10 | polymer | 185 | 21282.1 | 1 | UniProt (Q9UM13) Pfam (PF03256) In PDB | Homo sapiens (human) | APC10,Cyclosome subunit 10 |
| 2 | D | Anaphase-promoting complex subunit 15 | polymer | 121 | 14286.7 | 1 | UniProt (P60006) Pfam (PF15243) In PDB | Homo sapiens (human) | APC15 |
| 3 | A | Anaphase-promoting complex subunit 1 | polymer | 1944 | 216725.5 | 1 | UniProt (Q9H1A4) Pfam (PF12859) Pfam (PF20518) Pfam (PF21282) Pfam (PF18122) In PDB | Homo sapiens (human) | APC1,Cyclosome subunit 1,Mitotic checkpoint regulator,Testis-specific gene 24 protein |
| 4 | N | Anaphase-promoting complex subunit 2 | polymer | 822 | 93939.0 | 1 | UniProt (Q9UJX6) Pfam (PF00888) Pfam (PF08672) In PDB | Homo sapiens (human) | APC2,Cyclosome subunit 2 |
| 5 | I | Anaphase-promoting complex subunit 4 | polymer | 814 | 93014.1 | 1 | UniProt (Q9UJX5) Pfam (PF12894) Pfam (PF12896) In PDB | Homo sapiens (human) | APC4,Cyclosome subunit 4 |
| 6 | O | Anaphase-promoting complex subunit 5 | polymer | 755 | 85179.8 | 1 | UniProt (Q9UJX4) Pfam (PF21371) Pfam (PF12862) In PDB | Homo sapiens (human) | APC5,Cyclosome subunit 5 |
| 7 | S | F-box only protein 5 | polymer | 447 | 50227.5 | 1 | UniProt (Q9UKT4) Pfam (PF00646) Pfam (PF22191) In PDB | Homo sapiens (human) | Early mitotic inhibitor 1 |
| 8 | K, Q | Cell division cycle protein 16 homolog | polymer | 620 | 71747.5 | 2 | UniProt (Q13042) Pfam (PF12895) Pfam (PF13424) In PDB | Homo sapiens (human) | Anaphase-promoting complex subunit 6,APC6,CDC16 homolog,CDC16Hs,Cyclosome subunit 6 |
| 9 | G, W | Anaphase-promoting complex subunit CDC26 | polymer | 85 | 9794.0 | 2 | UniProt (Q8NHZ8) Pfam (PF10471) In PDB | Homo sapiens (human) | Anaphase-promoting complex subunit 12,APC12,Cell division cycle protein 26 homolog |
| 10 | M | Anaphase-promoting complex subunit 13 | polymer | 74 | 8528.3 | 1 | UniProt (Q9BS18) Pfam (PF05839) In PDB | Homo sapiens (human) | APC13,Cyclosome subunit 13 |
| 11 | H | Anaphase-promoting complex subunit 16 | polymer | 110 | 11678.0 | 1 | UniProt (Q96DE5) Pfam (PF17256) In PDB | Homo sapiens (human) | APC16,Cyclosome subunit 16 |
| 12 | J, P | Cell division cycle protein 27 homolog | polymer | 824 | 91973.1 | 2 | UniProt (P30260) Pfam (PF12895) Pfam (PF00515) In PDB | Homo sapiens (human) | Anaphase-promoting complex subunit 3,APC3,CDC27 homolog,CDC27Hs,H-NUC |
| 13 | Y, Z | Anaphase-promoting complex subunit 7 | polymer | 599 | 66929.4 | 2 | UniProt (Q9UJX3) Pfam (PF13181) Pfam (PF13432) In PDB | Homo sapiens (human) | APC7,Cyclosome subunit 7 |
| 14 | U, V | Cell division cycle protein 23 homolog | polymer | 597 | 68921.0 | 2 | UniProt (Q9UJX2) Pfam (PF04049) In PDB | Homo sapiens (human) | Anaphase-promoting complex subunit 8,APC8,Cyclosome subunit 8 |
| 15 | R | Fizzy-related protein homolog | polymer | 496 | 55253.2 | 1 | UniProt (Q9UM11) Pfam (PF12894) Pfam (PF00400) In PDB | Homo sapiens (human) | Fzr,CDC20-like protein 1,Cdh1/Hct1 homolog,hCDH1 |
| 16 | C | Anaphase-promoting complex subunit 11 | polymer | 84 | 9854.6 | 1 | UniProt (Q9NYG5) Pfam (PF12861) In PDB | Homo sapiens (human) | APC11,Cyclosome subunit 11,Hepatocellular carcinoma-associated RING finger protein |
| 17 | C, N, S | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence modifications
I: 1 - 808 (UniProt: Q9UJX5)
| PDB | External Database | Details |
|---|---|---|
| Glu 809 | - | expression tag |
| Asn 810 | - | expression tag |
| Leu 811 | - | expression tag |
| Tyr 812 | - | expression tag |
| Phe 813 | - | expression tag |
| Gln 814 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 1278698.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 1279091.3 |
