7QC1
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum in complex with MAT436
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, D, I) | Proline--tRNA ligase | polymer | 504 | 58526.9 | 3 | UniProt (Q8I5R7) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Plasmodium falciparum (isolate 3D7) | Prolyl-tRNA synthetase,ProRS |
| 2 | D, J, M (A, D, I) | [(2~{R},3~{S})-2-[3-(7-bromanyl-6-chloranyl-4-oxidanylidene-quinazolin-3-yl)-2-oxidanylidene-propyl]piperidin-3-yl] ~{N}-[4-[[3-(2,3-dihydro-1~{H}-inden-2-ylcarbamoyl)pyrazin-2-yl]carbamoyl]piperazin-1-yl]sulfonylcarbamate | non-polymer | 886.2 | 3 | Chemie (9XM) | |||
| 3 | E, F, G, H, I... (A, D, I) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 4 | Q, R, S (A, D, I) | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A, D, I: 249 - 746 (UniProt: Q8I5R7)
| PDB | External Database | Details |
|---|---|---|
| Ser 243 | - | expression tag |
| Asp 244 | - | expression tag |
| Asn 245 | - | expression tag |
| Ala 246 | - | expression tag |
| Ile 247 | - | expression tag |
| Ala 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 175580.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 3279.2 | |
| All* | Total formula weight | 178860.0 |
