7QBO
Structure of the activation intermediate of cathepsin K in complex with the azadipeptide nitrile inhibitor Gu1303
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cathepsin K | polymer | 216 | 23680.7 | 1 | UniProt (P43235) Pfam (PF00112) | Homo sapiens (human) | Cathepsin O,Cathepsin O2,Cathepsin X |
| 2 | B (P) | Cathepsin K | polymer | 74 | 8979.2 | 1 | UniProt (P43235) Pfam (PF08246) | Homo sapiens (human) | Cathepsin O,Cathepsin O2,Cathepsin X |
| 3 | C (A) | (phenylmethyl) ~{N}-[(2~{S})-1-[[aminomethyl(methyl)amino]-methyl-amino]-1-oxidanylidene-3-phenyl-propan-2-yl]carbamate | non-polymer | 370.4 | 1 | Chemie (9ZG) | |||
| 4 | D, E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | H (P) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | I, J (A, P) | water | water | 18.0 | 289 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32659.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 616.4 | |
| All* | Total formula weight | 33276.3 |
