7QBM
Structure of the activation intermediate of cathepsin K in complex with the 3-cyano-3-aza-beta-amino acid inhibitor Gu2602
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cathepsin K | polymer | 216 | 23680.7 | 1 | UniProt (P43235) Pfam (PF00112) | Homo sapiens (human) | Cathepsin O,Cathepsin O2,Cathepsin X |
| 2 | B (P) | Cathepsin K | polymer | 74 | 8979.2 | 1 | UniProt (P43235) Pfam (PF08246) | Homo sapiens (human) | Cathepsin O,Cathepsin O2,Cathepsin X |
| 3 | C (A) | ~{tert}-butyl ~{N}-[iminomethyl-[2-[methyl-(phenylmethyl)amino]-2-oxidanylidene-ethyl]amino]carbamate | non-polymer | 320.4 | 1 | Chemie (A0U) | |||
| 4 | D (P) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | E (P) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F, G (A, P) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32659.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 403.7 | |
| All* | Total formula weight | 33063.6 |
