7Q7L

JAK2 in complex with 4-(2-amino-8-{[(2S)-1-hydroxypropan-2-yl]amino}quinazolin-6-yl)-5-ethyl-2-fluorophenol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase JAK2	polymer	316	37454.3	1	UniProt (O60674) Pfam (PF07714) In PDB	Homo sapiens (Human)	Janus kinase 2,JAK-2
2	A	4-[2-azanyl-8-[[(2~{S})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol	non-polymer		356.4	1	Chemie (9I2)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4		water	water		18.0	195	Chemie (HOH)

Sequence modifications

A: 839 - 1132 (UniProt: O60674)

PDB	External Database	Details
Met 817	-	initiating methionine
His 818	-	expression tag
His 819	-	expression tag
His 820	-	expression tag
His 821	-	expression tag
His 822	-	expression tag
His 823	-	expression tag
Asp 824	-	expression tag
Tyr 825	-	expression tag
Lys 826	-	expression tag
Asp 827	-	expression tag
Asp 828	-	expression tag
Asp 829	-	expression tag
Asp 830	-	expression tag
Lys 831	-	expression tag
Glu 832	-	expression tag
Asn 833	-	expression tag
Leu 834	-	expression tag
Tyr 835	-	expression tag
Phe 836	-	expression tag
Gln 837	-	expression tag
Gly 838	-	expression tag
Ser 1073	Met 1073	conflict
Thr 1076	Phe 1076	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37454.3
Non-Polymers*	Number of molecules	2
	Total formula weight	448.5
All*	Total formula weight	37902.8

*Water molecules are not included.