7Q7K
JAK2 in complex with 4-(2-amino-8-methoxyquinazolin-6-yl)phenol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase JAK2 | polymer | 316 | 37454.3 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
2 | A | 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol | non-polymer | 267.3 | 1 | Chemie (9I5) | |||
3 | water | water | 18.0 | 307 | Chemie (HOH) |
Sequence modifications
A: 839 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Met 817 | - | initiating methionine |
His 818 | - | expression tag |
His 819 | - | expression tag |
His 820 | - | expression tag |
His 821 | - | expression tag |
His 822 | - | expression tag |
His 823 | - | expression tag |
Asp 824 | - | expression tag |
Tyr 825 | - | expression tag |
Lys 826 | - | expression tag |
Asp 827 | - | expression tag |
Asp 828 | - | expression tag |
Asp 829 | - | expression tag |
Asp 830 | - | expression tag |
Lys 831 | - | expression tag |
Glu 832 | - | expression tag |
Asn 833 | - | expression tag |
Leu 834 | - | expression tag |
Tyr 835 | - | expression tag |
Phe 836 | - | expression tag |
Gln 837 | - | expression tag |
Gly 838 | - | expression tag |
Ser 1073 | Met 1073 | conflict |
Thr 1076 | Phe 1076 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37454.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 267.3 | |
All* | Total formula weight | 37721.6 |