7Q5X

HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-2 ALPHA CODD (523-542)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Egl nine homolog 1	polymer	233	26036.6	1	UniProt (Q9GZT9) Pfam (PF13640)	Homo sapiens (Human)	Hypoxia-inducible factor prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20
2	B (B)	Endothelial PAS domain-containing protein 1	polymer	20	2309.5	1	UniProt (Q99814) Pfam (PF11413)	Homo sapiens	EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2
3	C (A)	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN)
4	D (A)	2-OXOGLUTARIC ACID	non-polymer		146.1	1	Chemie (AKG)
5	E (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
6	F, H, I, J, K... (A, B)	FORMIC ACID	non-polymer		46.0	11	Chemie (FMT)
7	G (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
8	Q, R, S (A)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
9	T, U, V (A)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
10	X, Y (A, B)	water	water		18.0	147	Chemie (HOH)

Sequence modifications

A: 181 - 407 (UniProt: Q9GZT9)

PDB	External Database	Details
Gly 175	-	expression tag
Ser 176	-	expression tag
His 177	-	expression tag
Met 178	-	expression tag
Ala 179	-	expression tag
Ser 180	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	28346.1
Non-Polymers*	Number of molecules	21
	Total formula weight	1084.8
All*	Total formula weight	29430.9

*Water molecules are not included.