7Q4A
Toxoplasma gondii PRP4K kinase domain (L715F) bound to altiratinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Non-specific serine/threonine protein kinase | polymer | 370 | 42877.2 | 2 | UniProt (S7UT92) Pfam (PF00069) In PDB | Toxoplasma gondii | |
2 | A, B | Altiratinib | non-polymer | 510.5 | 2 | Chemie (A9I) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
5 | B | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
6 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 362 (UniProt: S7UT92)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Ser 39 | Cys 571 | conflict |
Phe 183 | Leu 715 | conflict |
His 363 | - | expression tag |
His 364 | - | expression tag |
His 365 | - | expression tag |
His 366 | - | expression tag |
His 367 | - | expression tag |
His 368 | - | expression tag |
His 369 | - | expression tag |
His 370 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 85754.4 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1277.2 | |
All* | Total formula weight | 87031.6 |