7Q2G

mycolic acid methyltransferase Hma (MmaA4) from Mycobac-terium tuberculosis in complex with ZT726

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hydroxymycolate synthase MmaA4	polymer	318	36521.3	1	UniProt (Q79FX8) Pfam (PF02353) In PDB	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	Mycolic acid methyltransferase,MA-MT,S-adenosylmethionine-dependent methyltransferase,AdoMet-MT,SAM-MT
2	A	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
3	A	8-oxidanylquinoline-2-carbaldehyde	non-polymer		173.2	1	Chemie (8MJ)
4	A	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
5		water	water		18.0	55	Chemie (HOH)

Sequence modifications

A: 4 - 301 (UniProt: Q79FX8)

PDB	External Database	Details
Met -16	-	initiating methionine
Gly -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag
Tyr -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Ser -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Leu -3	-	expression tag
Val -2	-	expression tag
Pro -1	-	expression tag
Arg 0	-	expression tag
Gly 1	-	expression tag
Ser 2	-	expression tag
His 3	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36521.3
Non-Polymers*	Number of molecules	5
	Total formula weight	357.7
All*	Total formula weight	36879.0

*Water molecules are not included.