7Q0C
Mimic carbonic anhydrase IX in complex with Methyl 2-chloro-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Carbonic anhydrase 2 | polymer | 260 | 29243.0 | 2 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
| 2 | C, G (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, H (A, B) | methyl 2-chloranyl-4-cyclohexylsulfanyl-5-sulfamoyl-benzoate | non-polymer | 363.9 | 2 | Chemie (7VZ) | |||
| 4 | E (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | F, I (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 602 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 260 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | engineered mutation |
| Gln 67 | Asn 67 | engineered mutation |
| Leu 91 | Ile 91 | engineered mutation |
| Val 130 | Phe 130 | engineered mutation |
| Leu 134 | Val 134 | engineered mutation |
| Ala 203 | Leu 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58486.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1073.9 | |
| All* | Total formula weight | 59559.9 |
