7PXX
The crystal structure of Leishmania major Pteridine Reductase 1 in complex with substrate folic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Pteridine reductase 1 | polymer | 288 | 30456.6 | 1 | UniProt (Q01782) Pfam (PF00106) Pfam (PF13561) | Leishmania major | H region methotrexate resistance protein |
| 2 | B, C, D (B, C, D) | Pteridine reductase 1 | polymer | 288 | 30456.6 | 3 | UniProt (Q01782) Pfam (PF00106) Pfam (PF13561) | Leishmania major | H region methotrexate resistance protein |
| 3 | E, H, O, Q (A, B, C, D) | FOLIC ACID | non-polymer | 441.4 | 4 | Chemie (FOL) | |||
| 4 | F, I, P, R (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 5 | G, J (A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 6 | K, L, M, S (B, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | N (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | T, U, V, W (A, B, C, D) | water | water | 18.0 | 622 | Chemie (HOH) |
Sequence modifications
A: 1 - 288 (UniProt: Q01782)
B, C, D: 1 - 288 (UniProt: Q01782)
| PDB | External Database | Details |
|---|---|---|
| Val 162 | Phe 162 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 162 | Phe 162 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 121826.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 5522.1 | |
| All* | Total formula weight | 127348.4 |
