7PXX
The crystal structure of Leishmania major Pteridine Reductase 1 in complex with substrate folic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Pteridine reductase 1 | polymer | 288 | 30456.6 | 1 | UniProt (Q01782) Pfam (PF13561) In PDB | Leishmania major | H region methotrexate resistance protein |
2 | B, C, D | Pteridine reductase 1 | polymer | 288 | 30456.6 | 3 | UniProt (Q01782) Pfam (PF13561) In PDB | Leishmania major | H region methotrexate resistance protein |
3 | A, B, C, D | FOLIC ACID | non-polymer | 441.4 | 4 | Chemie (FOL) | |||
4 | A, B, C, D | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
5 | A, B | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
6 | B, D | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
7 | B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
8 | water | water | 18.0 | 622 | Chemie (HOH) |
Sequence modifications
A: 1 - 288 (UniProt: Q01782)
B, C, D: 1 - 288 (UniProt: Q01782)
PDB | External Database | Details |
---|---|---|
Val 162 | Phe 162 | conflict |
PDB | External Database | Details |
---|---|---|
Val 162 | Phe 162 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 121826.3 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 5522.1 | |
All* | Total formula weight | 127348.4 |