7PW4

Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1	polymer	3657	397395.4	1	UniProt (Q96Q15) Pfam (PF15785) Pfam (PF00454) Pfam (PF02260) In PDB	Homo sapiens (Human)	SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein
2	B	Protein SMG8	polymer	991	109825.8	1	UniProt (Q8ND04) Pfam (PF10220) In PDB	Homo sapiens (Human)	Amplified in breast cancer gene 2 protein,Protein smg-8 homolog
3	C	Protein SMG9	polymer	520	57717.5	1	UniProt (Q9H0W8) In PDB	Homo sapiens (Human)	Protein SMG-9
4	A	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	1	Chemie (IHP)
5	A	1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea	non-polymer		566.1	1	Chemie (88C)
6	C	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
7	C	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A: 1 - 310 (PDB: 7PW4)
A: 311 - 1638 (UniProt: Q96Q15)

PDB	External Database	Details
Arg 743	Lys 743	conflict
Ser 1209	Ala 1209	conflict

A: 1638 - 1726 (PDB: 7PW4)
A: 1727 - 1978 (UniProt: Q96Q15)
A: 1978 - 2034 (PDB: 7PW4)
A: 2035 - 2056 (UniProt: Q96Q15)
A: 2057 - 2087 (PDB: 7PW4)
A: 2088 - 3661 (UniProt: Q96Q15)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.