7PW4
Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1 | polymer | 3657 | 397395.4 | 1 | UniProt (Q96Q15) Pfam (PF15785) Pfam (PF00454) Pfam (PF02260) | Homo sapiens (Human) | SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein |
| 2 | B (B) | Protein SMG8 | polymer | 991 | 109825.8 | 1 | UniProt (Q8ND04) Pfam (PF10220) | Homo sapiens (Human) | Amplified in breast cancer gene 2 protein,Protein smg-8 homolog |
| 3 | C (C) | Protein SMG9 | polymer | 520 | 57717.5 | 1 | UniProt (Q9H0W8) | Homo sapiens (Human) | Protein SMG-9 |
| 4 | D (A) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 5 | E (A) | 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea | non-polymer | 566.1 | 1 | Chemie (88C) | |||
| 6 | F (C) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 7 | G (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 1 - 310 (PDB: 7PW4)
A: 311 - 1638 (UniProt: Q96Q15)
A: 1638 - 1726 (PDB: 7PW4)
A: 1727 - 1978 (UniProt: Q96Q15)
A: 1978 - 2034 (PDB: 7PW4)
A: 2035 - 2056 (UniProt: Q96Q15)
A: 2057 - 2087 (PDB: 7PW4)
A: 2088 - 3661 (UniProt: Q96Q15)
A: 311 - 1638 (UniProt: Q96Q15)
| PDB | External Database | Details |
|---|---|---|
| Arg 743 | Lys 743 | conflict |
| Ser 1209 | Ala 1209 | conflict |
A: 1727 - 1978 (UniProt: Q96Q15)
A: 1978 - 2034 (PDB: 7PW4)
A: 2035 - 2056 (UniProt: Q96Q15)
A: 2057 - 2087 (PDB: 7PW4)
A: 2088 - 3661 (UniProt: Q96Q15)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 564938.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1757.6 | |
| All* | Total formula weight | 566696.2 |
