7PW3

PARP15 catalytic domain in complex with OUL217

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Protein mono-ADP-ribosyltransferase PARP15	polymer	221	25439.5	2	UniProt (Q460N3) Pfam (PF00644) In PDB	Homo sapiens (Human)	ADP-ribosyltransferase diphtheria toxin-like 7,ARTD7,B-aggressive lymphoma protein 3,Poly [ADP-ribose] polymerase 15,PARP-15
2	A	4-(cyclohexylmethoxy)benzamide	non-polymer		233.3	1	Chemie (8C7)
3	B	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
4		water	water		18.0	338	Chemie (HOH)

Sequence modifications

A, B: 481 - 678 (UniProt: Q460N3)

PDB	External Database	Details
Met 458	-	initiating methionine
His 459	-	expression tag
His 460	-	expression tag
His 461	-	expression tag
His 462	-	expression tag
His 463	-	expression tag
His 464	-	expression tag
Ser 465	-	expression tag
Ser 466	-	expression tag
Gly 467	-	expression tag
Val 468	-	expression tag
Asp 469	-	expression tag
Leu 470	-	expression tag
Gly 471	-	expression tag
Thr 472	-	expression tag
Glu 473	-	expression tag
Asn 474	-	expression tag
Leu 475	-	expression tag
Tyr 476	-	expression tag
Phe 477	-	expression tag
Gln 478	-	expression tag
Ser 479	-	expression tag
Met 480	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50878.9
Non-Polymers*	Number of molecules	2
	Total formula weight	311.4
All*	Total formula weight	51190.4

*Water molecules are not included.