7PVX
Crystal structure of the c-Src SH3 domain mutant E93V-S94A-R95S-T96G-N112G-N113Y-T114N-E115H in complex with the synthetic peptide VSL12
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Isoform 1 of Proto-oncogene tyrosine-protein kinase Src | polymer | 60 | 6603.2 | 2 | UniProt (P00523-1) Pfam (PF00018) UniProt (by SIFTS) (P00523) | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | B, D (B, D) | VSL12 peptide | polymer | 12 | 1317.6 | 2 | synthetic construct | ||
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A, C: 82 - 141 (UniProt: P00523-1)
| PDB | External Database | Details |
|---|---|---|
| Val 93 | Glu 93 | engineered mutation |
| Ala 94 | Ser 94 | engineered mutation |
| Ser 95 | Arg 95 | engineered mutation |
| Gly 96 | Thr 96 | engineered mutation |
| Gly 112 | Asn 112 | engineered mutation |
| Tyr 113 | Asn 113 | engineered mutation |
| Asn 114 | Thr 114 | engineered mutation |
| His 115 | Glu 115 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 15841.7 | |
| All* | Total formula weight | 15841.7 |
