7PVW
Crystal structure of the intertwined dimer of the c-Src SH3 domain E93V-S94A-R95S-T96G-N112G-N113Y-T114N-E115H mutant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Isoform 1 of Proto-oncogene tyrosine-protein kinase Src | polymer | 60 | 6603.2 | 2 | UniProt (P00523-1) Pfam (PF00018) UniProt (by SIFTS) (P00523) In PDB | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
2 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
3 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
4 | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B: 82 - 141 (UniProt: P00523-1)
PDB | External Database | Details |
---|---|---|
Val 93 | Glu 93 | engineered mutation |
Ala 94 | Ser 94 | engineered mutation |
Ser 95 | Arg 95 | engineered mutation |
Gly 96 | Thr 96 | engineered mutation |
Gly 112 | Asn 112 | engineered mutation |
Tyr 113 | Asn 113 | engineered mutation |
Asn 114 | Thr 114 | engineered mutation |
His 115 | Glu 115 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 13206.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 253.3 | |
All* | Total formula weight | 13459.7 |