7PVW
Crystal structure of the intertwined dimer of the c-Src SH3 domain E93V-S94A-R95S-T96G-N112G-N113Y-T114N-E115H mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 1 of Proto-oncogene tyrosine-protein kinase Src | polymer | 60 | 6603.2 | 2 | UniProt (P00523-1) Pfam (PF00018) UniProt (by SIFTS) (P00523) | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | C (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 3 | D (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B: 82 - 141 (UniProt: P00523-1)
| PDB | External Database | Details |
|---|---|---|
| Val 93 | Glu 93 | engineered mutation |
| Ala 94 | Ser 94 | engineered mutation |
| Ser 95 | Arg 95 | engineered mutation |
| Gly 96 | Thr 96 | engineered mutation |
| Gly 112 | Asn 112 | engineered mutation |
| Tyr 113 | Asn 113 | engineered mutation |
| Asn 114 | Thr 114 | engineered mutation |
| His 115 | Glu 115 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13206.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 253.3 | |
| All* | Total formula weight | 13459.7 |
