7PVV
Crystal structure of the Abl SH3 domain G92N-Y93N-N94T-H95E mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bcr-abl1 e6a2 chimeric protein | polymer | 59 | 6476.1 | 1 | UniProt (A2RQD6) Pfam (PF00018) UniProt (by SIFTS) (P00519) | Homo sapiens (Human) | |
| 2 | B (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 3 | C (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 4 | D (A) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A: 63 - 120 (UniProt: A2RQD6)
| PDB | External Database | Details |
|---|---|---|
| Gly 62 | - | expression tag |
| Asn 92 | Gly 431 | engineered mutation |
| Asn 93 | Tyr 432 | engineered mutation |
| Thr 94 | Asn 433 | engineered mutation |
| Glu 95 | His 434 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 6476.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 256.3 | |
| All* | Total formula weight | 6732.4 |
