7PS0

Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with beta-24 Fabs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (E, A)	Spike protein S1	polymer	210	23646.6	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2
2	B, E (H, B)	Beta-24 heavy chain	polymer	228	24294.3	2		Homo sapiens (Human)
3	C, F (L, C)	Beta-24 light chain	polymer	216	22883.2	2		Homo sapiens (Human)
4	G, K (E, A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	H, I, J, L, M... (H, L, B, C)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)

Sequence modifications

E, A: 333 - 526 (UniProt: P0DTC2)

PDB	External Database	Details
Met 319	-	initiating methionine
Gly 320	-	expression tag
Cys 321	-	expression tag
Val 322	-	expression tag
Ala 323	-	expression tag
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Asn 417	Lys 417	variant
Lys 484	Glu 484	variant
Tyr 501	Asn 501	variant
Lys 527	-	expression tag
Lys 528	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	141648.1
Non-Polymers*	Number of molecules	8
	Total formula weight	1018.8
All*	Total formula weight	142666.9

*Water molecules are not included.