7PRY

Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with COVOX-45 and beta-6 Fabs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (A, F)	COVOX-45 Fab heavy chain	polymer	226	24187.2	2		Homo sapiens (Human)
2	B, G (B, G)	COVOX-45 Fab light chain	polymer	214	23359.8	2		Homo sapiens (Human)
3	C, H (H, C)	Beta-6 Fab heavy chain	polymer	228	24377.3	2		Homo sapiens (Human)
4	D, I (L, D)	Beta-6 Fab light chain	polymer	215	23652.2	2		Homo sapiens (Human)
5	E, J (E, I)	Spike protein S1	polymer	210	23646.6	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2
6	K, L (J, K)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)

Sequence modifications

E, I: 333 - 526 (UniProt: P0DTC2)

PDB	External Database	Details
Met 319	-	initiating methionine
Gly 320	-	expression tag
Cys 321	-	expression tag
Val 322	-	expression tag
Ala 323	-	expression tag
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Asn 417	Lys 417	variant
Lys 484	Glu 484	variant
Tyr 501	Asn 501	variant
Lys 527	-	expression tag
Lys 528	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	238446.0
Branched	Number of molecules	2
	Total formula weight	1141.1
All*	Total formula weight	239587.1

*Water molecules are not included.