7PQZ

Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with FI-3A and FD-11A Fabs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (E)	Spike protein S1	polymer	205	23150.9	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
2	B (H)	FI-3A Fab heavy chain	polymer	222	23521.4	1		Homo sapiens (Human)
3	C (L)	FI-3A Fab light chain	polymer	214	23364.8	1		Homo sapiens (Human)
4	D (A)	FD-11A Fab heavy chain	polymer	232	25032.1	1		Homo sapiens (Human)
5	E (B)	FD-11A Fab light chain	polymer	219	23024.4	1		Homo sapiens (Human)
6	F (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	G, H (E)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)

Sequence modifications

E: 333 - 526 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Lys 527	-	expression tag
Lys 528	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	118093.6
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	2
	Total formula weight	189.9
All*	Total formula weight	118708.0

*Water molecules are not included.