7PQQ
Structure of thermostabilised human NTCP in complex with Megabody 91
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | Sodium/bile acid cotransporter | polymer | 333 | 36652.4 | 1 | UniProt (Q14973) Pfam (PF01758) | Homo sapiens (human) | Cell growth-inhibiting gene 29 protein,Na(+)/bile acid cotransporter,Na(+)/taurocholate transport protein,Sodium/taurocholate cotransporting polypeptide,Solute carrier family 10 member 1, NTCP |
2 | B (B) | Anti-RON nanobody,Megabody 91,Glucosidase YgjK | polymer | 906 | 101583.0 | 1 | UniProt (P42592) Pfam (PF21152) Pfam (PF22422) | Lama glama (llama) | Megabody 91 |
Sequence modifications
A: 3 - 328 (UniProt: Q14973)
B: 1 - 12 (PDB: 7PQQ)
B: 13 - 187 (UniProt: P42592)
B: 188 - 906 (PDB: 7PQQ)
PDB | External Database | Details |
---|---|---|
Met 2 | - | initiating methionine |
Thr 5 | Asn 5 | engineered mutation |
Thr 11 | Asn 11 | engineered mutation |
Val 33 | Phe 33 | engineered mutation |
Ile 37 | Phe 37 | engineered mutation |
Asn 86 | Lys 86 | engineered mutation |
Ile 95 | Val 95 | engineered mutation |
Ile 107 | Val 107 | engineered mutation |
Leu 129 | Cys 129 | engineered mutation |
His 221 | Leu 221 | engineered mutation |
Leu 329 | - | expression tag |
Glu 330 | - | expression tag |
Val 331 | - | expression tag |
Leu 332 | - | expression tag |
Phe 333 | - | expression tag |
Gln 334 | - | expression tag |
B: 13 - 187 (UniProt: P42592)
B: 188 - 906 (PDB: 7PQQ)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 138235.4 | |
All* | Total formula weight | 138235.4 |