7PQG
Structure of thermostabilised human NTCP in complex with nanobody 87
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Nanobody 87 | polymer | 136 | 14988.5 | 1 | Lama glama | ||
2 | A | Sodium/bile acid cotransporter | polymer | 333 | 36652.4 | 1 | UniProt (Q14973) Pfam (PF01758) In PDB | Homo sapiens (Human) | Cell growth-inhibiting gene 29 protein,Na(+)/bile acid cotransporter,Na(+)/taurocholate transport protein,Sodium/taurocholate cotransporting polypeptide,Solute carrier family 10 member 1, NTCP |
Sequence modifications
A: 3 - 328 (UniProt: Q14973)
PDB | External Database | Details |
---|---|---|
Met 2 | - | initiating methionine |
Thr 5 | Asn 5 | engineered mutation |
Thr 11 | Asn 11 | engineered mutation |
Val 33 | Phe 33 | engineered mutation |
Ile 37 | Phe 37 | engineered mutation |
Asn 86 | Lys 86 | engineered mutation |
Ile 95 | Val 95 | engineered mutation |
Ile 107 | Val 107 | engineered mutation |
Leu 129 | Cys 129 | engineered mutation |
His 221 | Leu 221 | engineered mutation |
Leu 329 | - | expression tag |
Glu 330 | - | expression tag |
Val 331 | - | expression tag |
Leu 332 | - | expression tag |
Phe 333 | - | expression tag |
Gln 334 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 51640.9 | |
All* | Total formula weight | 51640.9 |