7PPN
SHP2 catalytic domain in complex with CD28 (183-198) phosphopeptide (pTyr-191, p-Thr-195)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11 | polymer | 282 | 32629.9 | 1 | UniProt (Q06124) Pfam (PF00102) | Homo sapiens (Human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3,Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3 |
| 2 | B (B) | T-cell-specific surface glycoprotein CD28 | polymer | 16 | 2198.3 | 1 | UniProt (P10747) | Homo sapiens | TP44 |
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 5 - 73 (UniProt: Q06124)
A: 78 - 282 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Gly 3 | - | expression tag |
| Ser 4 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | - | linker |
| Ser 75 | - | linker |
| Ser 76 | - | linker |
| Gly 77 | - | linker |
| Ser 213 | Cys 459 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34828.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 34920.3 |
