7PJH
Crystal structure of the human spliceosomal maturation factor AAR2 bound to the RNAse H domain of PRPF8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein AAR2 homolog | polymer | 401 | 45680.2 | 1 | UniProt (Q9Y312) Pfam (PF20981) Pfam (PF05282) | Homo sapiens (Human) | AAR2 splicing factor homolog |
| 2 | B (B) | Pre-mRNA-processing-splicing factor 8 | polymer | 259 | 29710.5 | 1 | UniProt (Q6P2Q9) Pfam (PF12134) | Homo sapiens (Human) | 220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220 |
| 3 | C, D (A, B) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A: 1 - 384 (UniProt: Q9Y312)
| PDB | External Database | Details |
|---|---|---|
| Met -27 | - | initiating methionine |
| Lys -26 | - | expression tag |
| His -25 | - | expression tag |
| His -24 | - | expression tag |
| His -23 | - | expression tag |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| Pro -19 | - | expression tag |
| Met -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Tyr -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Ile -13 | - | expression tag |
| Pro -12 | - | expression tag |
| Thr -11 | - | expression tag |
| Thr -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Asn -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| - | Val 161 | deletion |
| Ser 180 | Thr 170 | conflict |
| Ser 181 | Lys 171 | conflict |
| Ser 182 | Asp 172 | conflict |
| Ala 184 | Val 174 | conflict |
| Thr 186 | Gln 176 | conflict |
| Glu 187 | Asn 177 | conflict |
| Ile 188 | Leu 178 | conflict |
| Arg 189 | Pro 179 | conflict |
| Phe 190 | Arg 180 | conflict |
| Ser 191 | Cys 181 | conflict |
| Glu 192 | Gly 182 | conflict |
| Leu 193 | Ile 183 | conflict |
| Pro 194 | Glu 184 | conflict |
| Thr 195 | Cys 185 | conflict |
| Gln 196 | Lys 186 | conflict |
| Met 197 | Ser 187 | conflict |
| Phe 198 | Tyr 188 | conflict |
| Pro 199 | Gln 189 | conflict |
| - | Gly 191 | deletion |
| - | Leu 192 | deletion |
| - | Ala 193 | deletion |
| - | Arg 194 | deletion |
| - | Leu 195 | deletion |
| - | Pro 196 | deletion |
| - | Glu 197 | deletion |
| - | Met 198 | deletion |
| - | Lys 199 | deletion |
| - | Pro 200 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75390.6 | |
| All* | Total formula weight | 75390.6 |
