7PDQ
Crystal structure of a mutated form of RXRalpha ligand binding domain in complex with LG100268 and a coactivator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 245 | 27275.4 | 1 | UniProt (P28700) Pfam (PF00104) | Mus musculus (Mouse) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 1 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID | non-polymer | 363.5 | 1 | Chemie (LG2) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 333 | Chemie (HOH) |
Sequence modifications
A: 227 - 467 (UniProt: P28700)
| PDB | External Database | Details |
|---|---|---|
| Gly 223 | - | expression tag |
| Pro 224 | - | expression tag |
| His 225 | - | expression tag |
| Met 226 | - | expression tag |
| Glu 321 | Arg 321 | engineered mutation |
| Gln 437 | Cys 437 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28855.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 363.5 | |
| All* | Total formula weight | 29218.8 |
