7PB2

Crystal structure of JDI TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide (VVVGADGVGK)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F	MHC class I antigen	polymer	276	31952.2	2	UniProt (A0A583ZB34) Pfam (PF00129) Pfam (PF07654) In PDB	Homo sapiens (human)
2	B, G	Beta-2-microglobulin	polymer	100	11879.4	2	UniProt (P61769) Pfam (PF07654) In PDB	Homo sapiens (human)
3	C, H	KRAS G12D peptide (VVVGADGVGK)	polymer	10	901.0	2	UniProt (P01111) In PDB	Homo sapiens	Transforming protein N-Ras,GTPase NRas
4	D, I	TCR alpha	polymer	203	22749.0	2		Homo sapiens (Human)
5	E, J	TCR beta	polymer	245	27493.7	2		Homo sapiens (Human)

Sequence modifications

A, F: 1 - 275 (UniProt: A0A583ZB34)

PDB	External Database	Details
Pro 276	-	expression tag

B, G: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

C, H: 1 - 10 (UniProt: P01111)

PDB	External Database	Details
Asp 6	Gly 12	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	189950.5
All*	Total formula weight	189950.5

*Water molecules are not included.