7P74

The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ-binding motif of RSK1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Synaptojanin-2-binding protein,Annexin A2	polymer	421	47646.8	1	UniProt (P57105) UniProt (P07355) Pfam (PF00595) Pfam (PF00191)	Homo sapiens (Human)	Mitochondrial outer membrane protein 25,Annexin II,Annexin-2,Calpactin I heavy chain,Calpactin-1 heavy chain,Chromobindin-8,Lipocortin II,Placental anticoagulant protein IV,PAP-IV,Protein I,p36
2	B (B)	Ribosomal protein S6 kinase alpha-1	polymer	15	1829.0	1	UniProt (Q15418)	Homo sapiens	S6K-alpha-1,90 kDa ribosomal protein S6 kinase 1,p90-RSK 1,p90RSK1,p90S6K,MAP kinase-activated protein kinase 1a,MAPK-activated protein kinase 1a,MAPKAP kinase 1a,MAPKAPK-1a,Ribosomal S6 kinase 1,RSK-1
3	C, D, E, F (A)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
4	G, H (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	I (A)	water	water		18.0	232	Chemie (HOH)

Sequence modifications

A: 6 - 103 (UniProt: P57105)

PDB	External Database	Details
Gly 2	-	expression tag
Ser 3	-	expression tag
His 4	-	expression tag
Met 5	-	expression tag
Gly 104	-	linker

A: 105 - 422 (UniProt: P07355)

PDB	External Database	Details
Glu 149	Ala 66	conflict

B: 725 - 735 (UniProt: Q15418)

PDB	External Database	Details
Thr 721	-	linker
Asp 722	-	linker
Asp 723	-	linker
Ser 724	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	49475.8
Non-Polymers*	Number of molecules	6
	Total formula weight	344.5
All*	Total formula weight	49820.3

*Water molecules are not included.