7P5W
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Volume-regulated anion channel subunit LRRC8A | polymer | 810 | 94239.4 | 6 | UniProt (Q80WG5) Pfam (PF12534) Pfam (PF13855) | Mus musculus (Mouse) | Leucine-rich repeat-containing protein 8A,Protein ebouriffe,ebo |
| 2 | G, H, I, J, K... (K, L, G, H, I...) | synthetic nanobody Sb2 | polymer | 150 | 16748.3 | 6 | synthetic construct |
Sequence modifications
A, B, C, D, E, F: 15 - 808 (UniProt: Q80WG5)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Ile 2 | - | expression tag |
| Pro 3 | - | expression tag |
| Val 4 | - | expression tag |
| Thr 5 | - | expression tag |
| Glu 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Arg 8 | - | expression tag |
| Tyr 9 | - | expression tag |
| Phe 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Asp 12 | - | expression tag |
| Thr 13 | - | expression tag |
| Gln 14 | - | expression tag |
| Gln 809 | - | expression tag |
| Ala 810 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 665925.9 | |
| All* | Total formula weight | 665925.9 |
