7P5V

Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Volume-regulated anion channel subunit LRRC8A	polymer	810	94239.4	6	UniProt (Q80WG5)	Mus musculus (Mouse)	Leucine-rich repeat-containing protein 8A,Protein ebouriffe,ebo
2	G, H, I, J, K... (G, H, I, J, K...)	Synthetic nanobody Sb1	polymer	144	16036.6	6		synthetic construct

Sequence modifications

A, B, C, D, E, F: 15 - 808 (UniProt: Q80WG5)

PDB	External Database	Details
Met 1	-	initiating methionine
Ile 2	-	expression tag
Pro 3	-	expression tag
Val 4	-	expression tag
Thr 5	-	expression tag
Glu 6	-	expression tag
Leu 7	-	expression tag
Arg 8	-	expression tag
Tyr 9	-	expression tag
Phe 10	-	expression tag
Ala 11	-	expression tag
Asp 12	-	expression tag
Thr 13	-	expression tag
Gln 14	-	expression tag
Gln 809	-	expression tag
Ala 810	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	661655.9
All*	Total formula weight	661655.9

*Water molecules are not included.