7P3V
B-Raf V600E structure bound to a new inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase B-raf | polymer | 275 | 31420.0 | 2 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | C, D (A, B) | ~{N}-[3-[5-(2-azanylpyrimidin-4-yl)-2-[(3~{S})-morpholin-3-yl]-1,3-thiazol-4-yl]-2-fluoranyl-phenyl]-2,5-bis(fluoranyl)benzenesulfonamide | non-polymer | 548.6 | 2 | Chemie (5I4) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A, B: 448 - 719 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Phe 447 | - | expression tag |
| Ala 543 | Ile 543 | conflict |
| Ser 544 | Ile 544 | conflict |
| Lys 551 | Ile 551 | conflict |
| Arg 562 | Gln 562 | conflict |
| Asn 588 | Leu 588 | conflict |
| Glu 600 | Val 600 | engineered mutation |
| Ser 630 | Lys 630 | conflict |
| Glu 667 | Phe 667 | conflict |
| Ser 673 | Tyr 673 | conflict |
| Arg 688 | Ala 688 | conflict |
| Ser 706 | Leu 706 | conflict |
| Arg 709 | Gln 709 | conflict |
| Glu 713 | Ser 713 | conflict |
| Glu 716 | Leu 716 | conflict |
| Glu 720 | - | expression tag |
| Ala 721 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62840.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1097.1 | |
| All* | Total formula weight | 63937.2 |
