7P2Z
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with cyclosulfamidate 4
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (AAA, AaA) | Lysosomal alpha-glucosidase | polymer | 872 | 96978.6 | 2 | UniProt (P10253) Pfam (PF00088) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365) | Homo sapiens (Human) | Acid maltase,Aglucosidase alfa |
| 2 | C (BBB) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 3 | D, E (BcB, BeB) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | F (BgB) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | G (BjB) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | H, O, P, Q, R (AAA, AaA) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 7 | I, J, S, T, U... (AAA, AaA) | CHLORIDE ION | non-polymer | 35.5 | 9 | Chemie (CL) | |||
| 8 | AA, K, Z (AaA, AAA) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 9 | BA, CA, DA, L, M (AaA, AAA) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 10 | N (AaA) | (3~{a}~{R},4~{S},5~{S},6~{S},7~{R},7~{a}~{S})-7-(hydroxymethyl)-2,2-bis(oxidanylidene)-3~{a},4,5,6,7,7~{a}-hexahydro-3~{H}-benzo[d][1,2,3]oxathiazole-4,5,6-triol | non-polymer | 255.2 | 1 | Chemie (YTW) | |||
| 11 | EA, FA (AaA) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 12 | GA, HA (AAA, AaA) | water | water | 18.0 | 778 | Chemie (HOH) |
Sequence modifications
AAA, AaA: 81 - 952 (UniProt: P10253)
| PDB | External Database | Details |
|---|---|---|
| Arg 199 | His 199 | conflict |
| His 223 | Arg 223 | conflict |
| Ile 780 | Val 780 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 193957.3 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2373.2 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 1941.6 | |
| All* | Total formula weight | 198272.1 |
