7P0I
Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor Compound 13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor | polymer | 594 | 66360.6 | 1 | UniProt (P0AEX9) UniProt (O60894) UniProt (Q16602) Pfam (PF01547) Pfam (PF04901) Pfam (PF02793) In PDB | Escherichia coli (strain K12) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Calcitonin-receptor-like receptor activity-modifying protein 1,CRLR activity-modifying protein 1,CGRP type 1 receptor,Calcitonin receptor-like receptor |
| 2 | B | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | |||
| 3 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 4 | A | (1S,20E)-10-(benzofuran-3-ylmethyl)-12-methyl-15,18-dioxa-5,9,12,24,26-pentazapentacyclo[20.5.2.11,4.13,7.025,28]hentriaconta-3(30),4,6,20,22(29),23,25(28)-heptaene-8,11,27-trione | non-polymer | 607.7 | 1 | Chemie (7IU) | |||
| 5 | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A: 2 - 368 (UniProt: P0AEX9)
A: 1024 - 2025 (UniProt: O60894)
A: 2027 - 2144 (UniProt: Q16602)
| PDB | External Database | Details |
|---|---|---|
| Ala 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Asn 369 | - | linker |
| Ala 370 | - | linker |
| Ala 371 | - | linker |
| Ala 372 | - | linker |
| Glu 1022 | - | linker |
| Phe 1023 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 2026 | - | linker |
| Ser 2027 | - | linker |
| Ala 2027 | - | linker |
| Gly 2027 | - | linker |
| Ser 2027 | - | linker |
| Ala 2027 | - | linker |
| Gly 2027 | - | linker |
| Ser 2027 | - | linker |
| Ala 2027 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gln 2066 | Asn 66 | conflict |
| Gln 2118 | Asn 118 | conflict |
| Asp 2123 | Asn 123 | conflict |
| His 2145 | - | expression tag |
| His 2146 | - | expression tag |
| His 2147 | - | expression tag |
| His 2148 | - | expression tag |
| His 2149 | - | expression tag |
| His 2150 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 66360.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 996.1 | |
| All* | Total formula weight | 67699.0 |
