7OZV

SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with G

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Replicase polyprotein 1ab	polymer	932	106781.0	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	pp1ab,ORF1ab polyprotein
2	B	Non-structural protein 8	polymer	217	24161.4	1	UniProt (P0DTD1) Pfam (PF08717) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	nsp8
3	C	Non-structural protein 7	polymer	84	9279.8	1	UniProt (P0DTD1) Pfam (PF08716) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	nsp7
4	P	Product RNA	polymer	32	10258.1	1		synthetic construct
5	T	Template RNA	polymer	33	10539.3	1		synthetic construct
6	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

B: 1 - 198 (UniProt: P0DTD1)

PDB	External Database	Details
Met -18	-	initiating methionine
Gly -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

C: 1 - 81 (UniProt: P0DTD1)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	161019.6
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	161150.4

*Water molecules are not included.