7OZ1
Cryo-EM structure of ABCG1 E242Q mutant with ATP and cholesteryl hemisuccinate bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Isoform 4 of ATP-binding cassette sub-family G member 1 | polymer | 680 | 75658.5 | 2 | UniProt (P45844) Pfam (PF00005) Pfam (PF19055) Pfam (PF01061) In PDB | Homo sapiens (Human) | ATP-binding cassette transporter 8,White protein homolog |
| 2 | A, B | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | A, B | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 8 | Chemie (Y01) | |||
| 4 | A, B | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 2 | Chemie (PEE) |
Sequence modifications
A, B: 1 - 666 (UniProt: P45844)
| PDB | External Database | Details |
|---|---|---|
| Gln 242 | Glu 242 | engineered mutation |
| Ser 667 | - | linker |
| Ser 668 | - | linker |
| Arg 669 | - | linker |
| Val 670 | - | linker |
| Asp 671 | - | linker |
| Thr 672 | - | expression tag |
| Glu 673 | - | expression tag |
| Thr 674 | - | expression tag |
| Ser 675 | - | expression tag |
| Gln 676 | - | expression tag |
| Val 677 | - | expression tag |
| Ala 678 | - | expression tag |
| Pro 679 | - | expression tag |
| Ala 680 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 151317.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 6396.2 | |
| All* | Total formula weight | 157713.3 |
