7OWG

human DEPTOR in a complex with mutant human mTORC1 A1459P

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Serine/threonine-protein kinase mTOR	polymer	2549	287570.3	1	UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260) In PDB	Homo sapiens (Human)	FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1
2	E	Target of rapamycin complex subunit LST8	polymer	326	35910.1	1	UniProt (Q9BVC4) Pfam (PF00400) In PDB	Homo sapiens (Human)	TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8
3	O	DEP domain-containing mTOR-interacting protein	polymer	409	46365.8	1	UniProt (Q8TB45) Pfam (PF00610) In PDB	Homo sapiens (Human)	DEP domain-containing protein 6
4	Y	Regulatory-associated protein of mTOR	polymer	1335	149200.0	1	UniProt (Q8N122) Pfam (PF14538) Pfam (PF02985) Pfam (PF00400) In PDB	Homo sapiens (Human)	Raptor,p150 target of rapamycin (TOR)-scaffold protein

Sequence modifications

B: 1 - 16 (UniProt: P42345)
B: 17 - 30 (PDB: 7OWG)
B: 31 - 36 (UniProt: P42345)
B: 37 - 53 (PDB: 7OWG)
B: 54 - 355 (UniProt: P42345)

PDB	External Database	Details
Unk 60	Ser 60	conflict

B: 356 - 378 (PDB: 7OWG)
B: 379 - 2549 (UniProt: P42345)

PDB	External Database	Details
Pro 1459	Ala 1459	engineered mutation

O: 1 - 409 (UniProt: Q8TB45)

PDB	External Database	Details
Ser 204	Asn 204	variant
Asn 389	Ser 389	variant

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	519046.3
All*	Total formula weight	519046.3

*Water molecules are not included.