7OVN

Protein kinase MKK7 in complex with tolyl-substituted indazole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dual specificity mitogen-activated protein kinase kinase 7	polymer	318	36146.9	1	UniProt (O14733) Pfam (PF00069) In PDB	Homo sapiens (Human)	MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2
2	A	3-(1~{H}-indazol-3-yl)-~{N}-[[1-(2-methylphenyl)-1,2,3-triazol-4-yl]methyl]-5-(propanoylamino)benzamide	non-polymer		479.5	1	Chemie (2I8)

Sequence modifications

A: 117 - 424 (UniProt: O14733)

PDB	External Database	Details
Met 107	-	initiating methionine
Gly 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
His 114	-	expression tag
Ser 115	-	expression tag
Ala 116	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36146.9
Non-Polymers*	Number of molecules	1
	Total formula weight	479.5
All*	Total formula weight	36626.4

*Water molecules are not included.