7OUL
BDM88832 inhibitor bound to the transmembrane domain of AcrB-R971A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Multidrug efflux pump subunit AcrB | polymer | 1057 | 114650.2 | 3 | UniProt (P31224) Pfam (PF00873) In PDB | Escherichia coli | AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B |
2 | D, E | DARPIN | polymer | 169 | 18317.6 | 2 | synthetic construct | ||
3 | A, B, C | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 6 | Chemie (LMT) | |||
4 | C, D, E, A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
5 | A | 1-(3-chloranyl-5-iodanyl-pyridin-2-yl)piperazine | non-polymer | 323.6 | 1 | Chemie (1KE) | |||
6 | A | DODECANE | non-polymer | 170.3 | 1 | Chemie (D12) | |||
7 | C, A, B | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
8 | C, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
9 | C | (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate | non-polymer | 453.6 | 1 | Chemie (LPX) | |||
10 | C | DECYLAMINE-N,N-DIMETHYL-N-OXIDE | non-polymer | 201.3 | 1 | Chemie (DDQ) | |||
11 | C | TETRADECANE | non-polymer | 198.4 | 1 | Chemie (C14) | |||
12 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 1049 (UniProt: P31224)
PDB | External Database | Details |
---|---|---|
Ala 971 | Arg 971 | engineered mutation |
Leu 1050 | - | expression tag |
Glu 1051 | - | expression tag |
His 1052 | - | expression tag |
His 1053 | - | expression tag |
His 1054 | - | expression tag |
His 1055 | - | expression tag |
His 1056 | - | expression tag |
His 1057 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 380585.7 | |
Non-Polymers* | Number of molecules | 27 |
Total formula weight | 5566.0 | |
All* | Total formula weight | 386151.7 |