7OUH

Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, F, G (D, E, A, B)	Integrase	polymer	301	33943.5	4	UniProt (Q4QY51) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552)	Simian T-lymphotropic virus 1
2	C, H (F, C)	PC4 and SFRS1-interacting protein,Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	polymer	697	80394.7	2	Pfam (PF00855) Pfam (PF01603) UniProt (by SIFTS) (O75475) UniProt (by SIFTS) (Q13362)	Homo sapiens
3	D, I (I, K)	DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3')	polymer	30	9221.9	2		Simian T-lymphotropic virus 1
4	E, J (J, L)	DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3')	polymer	28	8593.6	2		Simian T-lymphotropic virus 1
5	K, L, P, Q (D, E, A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	M, N, R, S (E, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
7	O, T (E, B)	Bictegravir	non-polymer		449.4	2	Chemie (KLQ)
8	U, V, W, X (E, J, B, L)	water	water		18.0	6	Chemie (HOH)

Sequence modifications

D, E, A, B: 1 - 297 (UniProt: Q4QY51)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag
Glu 219	Ala 818	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	332194.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1257.6
All*	Total formula weight	333452.1

*Water molecules are not included.