7OUH

Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, F, G (D, E, A, B)	Integrase	polymer	301	33943.5	4	UniProt (Q4QY51)	Simian T-lymphotropic virus 1
2	C, H (F, C)	PC4 and SFRS1-interacting protein,Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	polymer	697	80394.7	2	Pfam (PF00855) Pfam (PF01603) UniProt (by SIFTS) (O75475) UniProt (by SIFTS) (Q13362)	Homo sapiens
3	D, I (I, K)	DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3')	polymer	30	9221.9	2		Simian T-lymphotropic virus 1
4	E, J (J, L)	DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3')	polymer	28	8593.6	2		Simian T-lymphotropic virus 1
5	K, L, P, Q (D, E, A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	M, N, R, S (E, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
7	O, T (E, B)	Bictegravir	non-polymer		449.4	2	Chemie (KLQ) PubChem (90242174) PubChem (90311989) PubChem (90328411) PubChem (130193042) PubChem (118596030) PubChem (118615004) PubChem (118660601) PubChem (146433978) PubChem (129130827) PubChem (132152471) PubChem (137706020) PubChem (138970569) PubChem (146300638) PubChem (156758090) PubChem (173849404) PubChem (174165821)
8	U, V, W, X (E, J, B, L)	water	water		18.0	6	Chemie (HOH)

Sequence modifications

D, E, A, B: 1 - 297 (UniProt: Q4QY51)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag
Glu 219	Ala 818	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	332194.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1257.6
All*	Total formula weight	333452.1

*Water molecules are not included.