7OUH
Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, E, A, B | Integrase | polymer | 301 | 33943.5 | 4 | UniProt (Q4QY51) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) In PDB | Simian T-lymphotropic virus 1 | |
2 | F, C | PC4 and SFRS1-interacting protein,Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | polymer | 697 | 80394.7 | 2 | Pfam (PF00855) Pfam (PF01603) UniProt (by SIFTS) (O75475) UniProt (by SIFTS) (Q13362) In PDB | Homo sapiens | |
3 | I, K | DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3') | polymer | 30 | 9221.9 | 2 | Simian T-lymphotropic virus 1 | ||
4 | J, L | DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3') | polymer | 28 | 8593.6 | 2 | Simian T-lymphotropic virus 1 | ||
5 | D, E, A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
6 | E, B | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
7 | E, B | Bictegravir | non-polymer | 449.4 | 2 | Chemie (KLQ) | |||
8 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
D, E, A, B: 1 - 297 (UniProt: Q4QY51)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Pro -2 | - | expression tag |
Glu -1 | - | expression tag |
Phe 0 | - | expression tag |
Glu 219 | Ala 818 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 332194.5 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1257.6 | |
All* | Total formula weight | 333452.1 |