7OTE
Src Kinase Domain in complex with ponatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Proto-oncogene tyrosine-protein kinase Src | polymer | 293 | 33585.4 | 2 | UniProt (P12931) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | A, B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 2 | Chemie (0LI) | |||
| 3 | A | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 4 | A, B | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, B: 254 - 536 (UniProt: P12931)
| PDB | External Database | Details |
|---|---|---|
| His 244 | - | expression tag |
| His 245 | - | expression tag |
| His 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
| His 249 | - | expression tag |
| Gly 250 | - | expression tag |
| Ser 251 | - | expression tag |
| Asp 252 | - | expression tag |
| Ile 253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67170.9 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2108.2 | |
| All* | Total formula weight | 69279.1 |
