7OTA

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-230

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, A	Reverse transcriptase/ribonuclease H	polymer	556	64022.4	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)	Exoribonuclease H,p66 RT
2	D, B	Reverse transcriptase/ribonuclease H	polymer	428	50039.5	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)	Exoribonuclease H,p51 RT
3	E, T	DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3')	polymer	27	8383.4	2		Human immunodeficiency virus type 1 BH10
4	F, P	DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3')	polymer	21	6474.3	2		Homo sapiens
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	A	((2-(6-amino-9H-purin-9-yl)ethyl)-L-seryl)phosphoramidic acid	non-polymer		345.3	1	Chemie (1I1)
7		water	water		18.0	3	Chemie (HOH)

Sequence modifications

C, A: 1 - 554 (UniProt: P03366)

PDB	External Database	Details
Met -1	-	initiating methionine
Val 0	-	expression tag
Cys 258	Gln 857	conflict
Ser 280	Cys 879	conflict
Asn 498	Asp 1097	conflict

D, B: 1 - 428 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 879	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	257839.1
Non-Polymers*	Number of molecules	2
	Total formula weight	369.6
All*	Total formula weight	258208.7

*Water molecules are not included.